City require a maximum of 15 points from their remaining 10 games to claim their third title and first under Pep Guardiola.
If they win their next three Premier League games then they could win it if they beat rivals Manchester United on April 7, assuming United keep winning and Liverpool drop any points.
City are unbeaten in their last 26 Premier League home games (W21 D5) since 3-1 defeat against Chelsea in 2016, which was the catalyst result for the Blues to go on to win the title.
While City are 18 points better off than at the same stage last season, Chelsea are 16 points worse off after a stuttering defence of the title.
Kyle Walker could miss out for Manchester City with a calf problem.
The England full-back limped out of Thursdays 3-0 win at Arsenal and is now a doubt for the visit of the reigning champions.
Raheem Sterling could also be absent as he overcomes a muscular problem, with Fernandinho (hamstring) and Benjamin Mendy (knee) definitely out and Fabian Delph banned.
Midfielder Ross Barkley could return to the Chelsea matchday squad.
Barkley has returned to training following a hamstring injury and head coach Antonio Conte is yet to decide whether or not to select the former Everton forward on the bench.
Defenders David Luiz (ankle) and Ethan Ampadu (hamstring) and midfielder Tiemoue Bakayoko (undisclosed) are out.
