The last four matches between these two sides have ended in draws, and Jose Mourinhos tactics have been criticised, having overseen two goalless draws in three matches against Liverpool as United boss.
His team came from 2-0 down to win 3-2 at Crystal Palace on Monday night to go two points ahead of third-place Liverpool, but in his pre-match press conference, the United boss claimed to still not fully grasp the rivalry between the two clubs.
He said: "I still dont know (how much this match means) because in my mentality every match is the same and Im not very good on that culture of this rivalry is special, that match is special - Ive never been very, very good at it.
"I never looked to AC Milan as the biggest rival (when I was at Inter Milan), I never looked at Atletico Madrid as the enemy (when at Real Madrid), I never looked to Spurs or to Arsenal as the big rival (when at Chelsea).
"Ive never been very, very good on it. For me, it is just a big match: two historical clubs not just in England but in the world."
Marouane Fellaini is back in contention for the game after being sidelined since January 31 with a knee complaint.
Veteran striker Zlatan Ibrahimovic is training and centre-back Eric Bailly is fully fit, but Ander Herrera, Marcos Rojo, Anthony Martial, Phil Jones and Daley Blind remain absent.
Jordan Henderson, Andrew Robertson and Georginio Wijnaldum are all available for Liverpool.
