City, who are 16 points clear at the top of the table, are just four wins away from securing the title. They have already won the Carabao Cup and are also through to the quarter-finals of the Champions League.
However, while Guardiola acknowledges that City are closing in on glory, he was also keen to stress the job is not completed yet.
"The distance is not normal in the beginning of March. Its like I said before, its almost done," he said.
"But we are not the champions. The champions are still Chelsea. We have to get the points as soon as possible, knowing that we have the opportunity.
"I know everyone wants to anticipate the situation and what will happen, everyone is thinking about when we will win the title.
"But the best example was two days ago. Nobody thought we could lose against Basel and we lost against Basel. We need to be relaxed, stay calm and think about Stoke City."
Meanwhile, Stoke boss Paul Lambert, whose side are 19th in the table, says he does not think there is an overall fitness issue with the squad.
"Its just my personal feeling of an individual," he said. "To get to my level you have to be really on it and I need them (Wimmer and Berahino) up to that level of what I see a footballer being like."
Stoke forward Mame Diouf is set to sit out the game with City due to the shoulder injury he sustained last weekend at Southampton.
Defender Kevin Wimmer and striker Saido Berahino, who have been placed on programmes to up their fitness levels, could return to the matchday squad after missing the last six and two games respectively.
Midfielder Stephen Ireland (calf) is not yet ready to make his comeback, and goalkeeper Lee Grant (broken wrist) also remain sidelined.
Meanwhile, City playmaker David Silva returns after missing the midweek Champions League clash against Basel for personal reasons.
Forward Raheem Sterling and midfielder Fernandinho are both hoping to prove their fitness after returning to training following hamstring injuries.
Left-back Fabian Delph is available again after suspension but could be doubtful after suffering a knock. Benjamin Mendy (knee) is also back in training and could return in the next month.
